Hello, my name is Syd and I am with Epson America
Normally this occurs when there is a corrupted app, or anti-virus blocking the window. Just to verify, when you un-install using USB, you always want to power off the scanner (device) first, then un-install using Windows control panel, restart the computer, and re-install. Do NOT power on the USB device until after the install or until you see a window in the installer to NOW power on the unit.
If you do not do this in exactly this way, plug/play may not release the old corrupted driver.
For 3rd party anti-virus, there may have been an auto update. Try selecting disable BOTH firewall and anti-virus as a test.
If these both do not work, you would need to contact Epson support at 562-276-4382 and a rep can help isolate the variable that caused this issue.