Try turning on the the Skip Blank Page setting in the Mac OS X 10.5/10.6 or Mac OS X 10.4 printer driver. To turn on Skip Blank Page in Windows, access your print settings, click the Maintenance tab, click Speed & Progress, then select Skip Blank Page.
Try printing a different document to determine if the problem is limited to one document. If it is, try recreating the document (with copy and paste, for example).
If you're using a USB connection, you may need to uninstall and reinstall the product software.