This could be caused by the hardware or software settings. Try one or more of these solutions:
Make sure the scanner is turned on.
Make sure that EPSON Scan is selected in your application software.
Turn off the scanner and the computer. Then check the connection between the scanner and the computer.
In the Device Manager menu, make sure your scanner's name appears under Imaging devices hardware type without a question (?) or exclamation (!) mark. If you see the ? or ! or the scanner appears as an Unknown devices hardware type, uninstall EPSON Scan. Then reinstall it following the instructions in your Start Here sheet.