Turn off the scanner and the computer. Then check the connection between the scanner and the computer.
Make sure that EPSON Scan is selected in your application software.
In Windows, check the Device Manager menu, and make sure your scanner’s name appears under Imaging devices hardware type without a question (?) or exclamation (!) mark. If you see the ? or ! or the scanner appears as an Unknown devices hardware type, uninstall EPSON Scan. Then reinstall it following the instructions on your Start Here sheet.