The P-5000 replaces the P-4000. The following table lists the major differences between the two models.
| | P-5000 | P-4000 |
| Image Display | 4.0-inch Epson VGA TFT LCD with 4 color filter; 640 x 480 pixels; 16,777,216 colors; 198 ppi | 3.8-inch Epson VGA TFT LCD; 640 × 480 pixels; 262,144 colors; 212 ppi |
| Epson LCD Technology | World’s first four-color LCD: New Photo Fine Ultra technology offers the world’s first 4-color filter system of red, emerald green, blue and yellow green, enabling images to be reproduced more accurately than ever before. | Epson Photo Fine technology 3-color pixel LCD - red, green, blue |
| Supported image files | JPEG (Up to 30 megapixels; Non-Progressive Scan only)
RAW (Not all RAW images are supported) | JPEG (Up to 17.8 megapixels; Non-Progressive Scan only)
RAW (Not all RAW images are supported) |
| Supported video files | MPEG 4, Motion JPEG, AVI, DivX, H.264, WMV9 | MPEG 4, Motion JPEG, AVI |
| Supported audio files | MP3, AAC, WMA | MP3, AAC |
| Adobe RGB color support (88% of color gamut) | Yes | No |
| USB device connectivity | Yes | No |
| Printer support | Direct Print via PictBridge to supported printers. | USB DIRECT PRINT driver supports the Stylus Photo R300, Stylus Photo 320, Stylus Photo RX600, PictureMate, and all other Epson inkjet printers that are USB DIRECT PRINT compatible. |
| Bundled software | Epson Link2 Version 1.10 (Windows/Mac OS X), Apple QuickTime ver. 7.1.0 (Windows Only) | Adobe Reader (5.1) for viewing the User’s Guide |